Professor David Moore

ɳ°ÍÌåÓý¹ÙÍø_2024Å·ÖÞ±­²©²Êapp@ me

David is a Paediatric Infectious Diseases subspecialist based at Chris Hani Baragwanath Academic Hospital, Johannesburg.

His chief areas of interest include management and research of childhood pneumonia, vaccine preventable diseases, antibiotic stewardship, paediatric HIV and tuberculosis.

He is the Divisional Head of Paediatric Infectious Diseases at the Faculty of Health Sciences, University of the Witwatersrand.

He is passionate about practicing and teaching evidence-based medicine within the fields of Paediatrics and Infectious Diseases.

Details

Email: david.moore@wits.ac.za

Office: 011 933 8400

Mobile: 083 297 2468 

Portfolios

Faculty Exec and Board (Wits), Professional and Ethical Standards Committee (Wits), Gauteng Provincial Health Research Committee, Child and Adolescent Subcommittee of the Southern African HIV Clinician’s Society, Sector Leader – Children’s Sector (Yezingane Network) of the South African National AIDS Council

Clinical Duties

In-patient: General Paediatrics, Infectious Disease Consultations, Outreach to referral hospitals

Outpatient: General Paediatric & Paediatric HIV Outpatient Clinics, Primary Immunodeficiency Disease (PID) Clinic

Academic: undergraduate and postgraduate teaching responsibilities

Research

Childhood pneumonia, antimicrobial stewardship, disease burden evaluation of paediatric pneumonia, meningitis, and other vaccine-preventable diseases, COVID-19 studies in children.

I have a special interest in data analysis and biostatistics

1.       Baillie VL, Moore DP, Mathunjwa A, Baggett HC, Brooks A, Feikin DR et al. Epidemiology of the Rhinovirus (RV) in African and Southeast Asian Children: A Case-Control Pneumonia Etiology Study. Viruses 2021;13.

2.       Chhiba PD, Moore DP, Levy C and Do Vale C. Factors associated with graft survival in South African adolescent renal transplant patients at CMJAH over a 20-year period (GRAFT-SAT Study). Pediatr Transplant 2021:e14148.

3.       Mabena FC, Baillie VL, Hale MJ, Thwala BN, Mthembu N, Els T et al. Clinical Characteristics and Histopathology of Coronavirus Disease 2019-Related Deaths in African Children. Pediatr Infect Dis J 2021;Online First. 67.

4.       Moore DP, Baillie VL, Mudau A, Wadula J, Adams T, Mangera S et al. The Etiology of Pneumonia in HIV-1-infected South African Children in the Era of Antiretroviral Treatment: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study. Pediatr Infect Dis J 2021;40:S69–s78.

5.       Moore DP, Baillie VL, Mudau A, Wadula J, Adams T, Mangera S et al. The Etiology of Pneumonia in HIV-uninfected South African Children: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study. Pediatr Infect Dis J 2021;40:S59–s68.

6.       Nunes MC, Baillie VL, Kwatra G, Bhikha S, Verwey C, Menezes C et al. SARS-CoV-2 infection among healthcare workers in South Africa: a longitudinal cohort study. Clin Infect Dis 2021.

7.       Park DE, Higdon MM, Prosperi C, Baggett HC, Brooks WA, Feikin DR et al. Upper Respiratory Tract Co-detection of Human Endemic Coronaviruses and High-density Pneumococcus Associated With Increased Severity Among HIV-Uninfected Children Under 5 Years Old in the PERCH Study. Pediatr Infect Dis J 2021;40:503–12.

8.       Wang X, Li Y, Deloria-Knoll M, Madhi SA, Cohen C, Ali A et al. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study. Lancet Glob Health 2021;9:e33–e43.

9.       Baillie VL, Moore DP, Mathunjwa A, Morailane P, Simões EAF and Madhi SA. A prospective case-control study on the association of Rhinovirus nasopharyngeal viral load and viremia in South African children hospitalized with severe pneumonia. J Clin Virol 2020;125:104288.

10.   Ebruke BE, Knoll MD, Haddix M, Zaman SMA, Prosperi C, Feikin DR et al. The Aetiology of pneumonia from analysis of Lung aspirate and Pleural fluid samples: Findings from the PERCH study. Clin Infect Dis 2020.

11.   Gallagher KE, Knoll MD, Prosperi C, Baggett HC, Brooks WA, Feikin DR et al. The Predictive Performance of a Pneumonia Severity Score in Human Immunodeficiency Virus-negative Children Presenting to Hospital in 7 Low- and Middle-income Countries. Clin Infect Dis 2020;70:1050–7.

12.   Johnstone SL, Moore DP, Klugman KP, Madhi SA and Groome MJ. Epidemiology of invasive bacterial infections in pneumococcal conjugate vaccine-vaccinated and -unvaccinated children under 5 years of age in Soweto, South Africa: a cohort study from a high-HIV burden setting. Paediatr Int Child Health 2020;40:50–7.

13.   Mahomed N, van Ginneken B, Philipsen R, Melendez J, Moore DP, Moodley H et al. Computer-aided diagnosis for World Health Organization-defined chest radiograph primary-endpoint pneumonia in children. Pediatr Radiol 2020;50:482–91.

14.   McCollum ED, Park DE, Watson NL, Fancourt NSS, Focht C, Baggett HC et al. Digital auscultation in PERCH: Associations with chest radiography and pneumonia mortality in children. Pediatr Pulmonol 2020.

15.   Moore DP, Green RJ, Cohen C, Itzikowitz G, Andronikou S, Argent AC et al. Epidemiology and aetiology of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 1). South African Medical Journal 2020;110.

16.   Reubenson G, Avenant T, Moore DP, Itzikowitz G, Andronikou S, Cohen C et al. Management of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 3). South African Medical Journal 2020;110.

17.   Zar H, Moore DP, Andronikou S, Argent AC, Avenant T, Cohen C et al. Diagnosis and management of community-acquired pneumonia in children: South African Thoracic Society guidelines. Afr J Thorac Crit Care Med 2020;26:AJTCCM.2020.v26i3.104.

18.   Zar HJ, Moore DP, Andronikou S, Argent AC, Avenant T, Cohen C et al. Prevention of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 4). South African Medical Journal 2020;110.

19.   Zar HJ, Moore DP, Itzikowitz G, Green RJ, Argent AC, Avenant T et al. Diagnosis of community-acquired pneumonia in children: South African Thoracic Society guidelines (part 2). South African Medical Journal 2020;110.

20.   Baillie VL, Moore DP, Mathunjwa A, Morailane P, Simoes EAF and Madhi SA. The molecular subtyping of Human rhinovirus (HRV) in children from three Sub-Saharan African countries. J Clin Microbiol 2019. pii: JCM.00723-19. doi: 10.1128/jcm.00723-19 [Epub ahead of print].

21.   Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C et al. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis. Lancet Glob Health 2019;7:e1031–e1045.

22.   The Pneumonia Etiology Research for Child Health (PERCH) Study Group. Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study. Lancet 2019;394:757–79.

23.   Motaze NV, Manamela J, Smit S, Rabie H, Harper K, du Plessis N et al. Congenital rubella syndrome surveillance in South Africa using a sentinel site approach: a cross-sectional study. Clin Infect Dis 2018;68:1658–64.

24.   Petersen KL, Moore DP and Kala UK. Posterior urethral valves in South African boys: Outcomes and challenges. S Afr Med J 2018;108:667–70.

25.   Baggett HC, Watson NL, Deloria Knoll M, Brooks WA, Feikin DR, Hammitt LL et al. Density of Upper Respiratory Colonization With Streptococcus pneumoniae and Its Role in the Diagnosis of Pneumococcal Pneumonia Among Children Aged <5 Years in the PERCH Study. Clin Infect Dis 2017;64:S317–27.

26.   Cohen C, von Mollendorf C, de Gouveia L, Lengana S, Meiring S, Quan V et al. Effectiveness of the13-valent pneumococcal conjugate vaccine against invasive pneumococcal disease in South African children: a case-control study. The Lancet Global Health 2017;5:e359–e369.

27.   Crawley J, Prosperi C, Baggett HC, Brooks WA, Deloria Knoll M, Hammitt LL et al. Standardization of Clinical Assessment and Sample Collection Across All PERCH Study Sites. Clin Infect Dis 2017;64:S228–37.

28.   DeLuca AN, Hammitt LL, Kim J, Higdon MM, Baggett HC, Brooks WA et al. Safety of Induced Sputum Collection in Children Hospitalized With Severe or Very Severe Pneumonia. Clin Infect Dis 2017;64:S301–8.

29.   Driscoll AJ, Deloria Knoll M, Hammitt LL, Baggett HC, Brooks WA, Feikin DR et al. The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia. Clin Infect Dis 2017;64:S368–77.

30.   Fancourt N, Deloria Knoll M, Baggett HC, Brooks WA, Feikin DR, Hammitt LL et al. Chest Radiograph Findings in Childhood Pneumonia Cases From the Multisite PERCH Study. Clin Infect Dis 2017;64:S262–70.

31.   Fancourt N, Deloria Knoll M, Barger-Kamate B, de Campo J, de Campo M, Diallo M et al. Standardized Interpretation of Chest Radiographs in Cases of Pediatric Pneumonia From the PERCH Study. Clin Infect Dis 2017;64:S253–61.

32.   Feikin DR, Fu W, Park DE, Shi Q, Higdon MM, Baggett HC et al. Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study. Clin Infect Dis 2017;64:S337–46.

33.   Higdon MM, Hammitt LL, Deloria Knoll M, Baggett HC, Brooks WA, Howie SRC et al. Should Controls With Respiratory Symptoms Be Excluded From Case-Control Studies of Pneumonia Etiology? Reflections From the PERCH Study. Clin Infect Dis 2017;64:S205–12.

34.   Higdon MM, Le T, O’Brien KL, Murdoch DR, Prosperi C, Baggett HC et al. Association of C-Reactive Protein With Bacterial and Respiratory Syncytial Virus–Associated Pneumonia Among Children Aged <5 Years in the PERCH Study. Clin Infect Dis 2017;64:S378–86.

35.   Jallow S, Madhi SA, Madimabe R, Sipambo N, Violari A, Kala U et al. Immunogenicity of 13-valent pneumococcal conjugate vaccine among children with underlying medical conditions. Vaccine 2017;35:4321–9.

36.   Mammen VG, Dangor Z, Moore DP, Izu A, Beylis N and Madhi SA. Hospitalization for Culture-Confirmed Pulmonary Tuberculosis in the Era of Childhood Pneumococcal Conjugate Vaccine Immunization. Pediatr Infect Dis J 2017;36:e14–e21.

37.   Deloria Knoll M, Morpeth SC, Scott JAG, Watson NL, Park DE, Baggett HC et al. Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study. Clin Infect Dis 2017;64:S357–67.

38.   McCollum ED, Park DE, Watson NL, Buck WC, Bunthi C, Devendra A et al. Listening panel agreement and characteristics of lung sounds digitally recorded from children aged 1-59 months enrolled in the Pneumonia Etiology Research for Child Health (PERCH) case-control study. BMJ Open Respir Res 2017;4:e000193.

39.   Moore DP, Higdon MM, Hammitt LL, Prosperi C, DeLuca AN, Da Silva P et al. The Incremental Value of Repeated Induced Sputum and Gastric Aspirate Samples for the Diagnosis of Pulmonary Tuberculosis in Young Children With Acute Community-Acquired Pneumonia. Clin Infect Dis 2017;64:S309–16.

40.   Moore DP, Murdoch DR, O’ Brien KL and Madhi SA. Reply to Drancourt. Clin Infect Dis 2017;65:2159.

41.   Morpeth SC, Deloria Knoll M, Scott JAG, Park DE, Watson NL, Baggett HC et al. Detection of Pneumococcal DNA in Blood by Polymerase Chain Reaction for Diagnosing Pneumococcal Pneumonia in Young Children From Low- and Middle-Income Countries. Clin Infect Dis 2017;64:S347–56.

42.   Murdoch DR, Morpeth SC, Hammitt LL, Driscoll AJ, Watson NL, Baggett HC et al. Microscopic Analysis and Quality Assessment of Induced Sputum From Children With Pneumonia in the PERCH Study. Clin Infect Dis 2017;64:S271–9.

43.   Murdoch DR, Morpeth SC, Hammitt LL, Driscoll AJ, Watson NL, Baggett HC et al. The Diagnostic Utility of Induced Sputum Microscopy and Culture in Childhood Pneumonia. Clin Infect Dis 2017;64:S280–8.

44.   Nzenze SA, Madhi SA, Shiri T, Klugman KP, de Gouveia L, Moore DP et al. Imputing the Direct and Indirect Effectiveness of Childhood Pneumococcal Conjugate Vaccine Against Invasive Pneumococcal Disease by Surveying Temporal Changes in Nasopharyngeal Pneumococcal Colonization. Am J Epidemiol 2017;186:435–44.

45.   Park DE, Baggett HC, Howie SRC, Shi Q, Watson NL, Brooks WA et al. Colonization Density of the Upper Respiratory Tract as a Predictor of Pneumonia – Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, and Pneumocystis jirovecii. Clin Infect Dis 2017;64:S328–36.

46.   Shi T, McAllister DA, O’Brien KL, Simões EAF, Madhi SA, Gessner BD et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet 2017;390:946–58.

47.   Smith AM, Smouse SL, Tau NP, Bamford C, Moodley VM, Jacobs C et al. Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa: phenotypic and genotypic analysis of isolates. BMC Infect Dis 2017;17:656.

48.   Thea DM, Seidenberg P, Park DE, Mwananyanda L, Fu W, Shi Q et al. Limited Utility of Polymerase Chain Reaction in Induced Sputum Specimens for Determining the Causes of Childhood Pneumonia in Resource-Poor Settings: Findings From the Pneumonia Etiology Research for Child Health (PERCH) Study. Clin Infect Dis 2017;64:S289–300.

49.   Watson NL, Prosperi C, Driscoll AJ, Higdon MM, Park DE, Sanza M et al. Data Management and Data Quality in PERCH, a Large International Case-Control Study of Severe Childhood Pneumonia. Clin Infect Dis 2017;64:S238–44.

Awards/Associations/Community activities

Best oral presentation at the Federation of Infectious Diseases Societies of Southern Africa (FIDSSA) 3 Congress 2009

Best oral presentation at the FIDSSA 8^th Congress 2019

Carnegie Post-Doctoral Clinician Fellowship 2020 to 2022

Associations: CMSA, FIDSSA, College of Paediatricians of South Africa