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Associate Prof Karl-Günter Technau

沙巴体育官网_2024欧洲杯博彩app@ me

Who am I? Senior Medical Officer in charge of Empilweni clinic (Paediatric HIV clinic RMMCH), Deputy Director ESRU (Syndicate of WHC)

What do I do?

Provide clinical service and supervision (Paeds HIV and starting off in palliative care work)
Supervision of research projects
Involvement in own research projects (HIV cohorts, Pregnancy Registry)
Teaching (under and Postgraduate Students and staff)

Details

Email: karl-gunter.technau@wits.ac.za
Office: 011 470 9421
Mobile: 086 553 5046

Clinical Duties

In-patient: Ward rounds, MDT meetings for palliative care
Outpatient: Running HIV clinics, MDT meetings for palliative care and advanced disease cases including significant psycho social problem cases

Research

Current research activities
IeDEA – Southern Africa – HIV cohort – Site lead RMMCH
UBOMI Buhle – National Pregnancy Registry: https://www.ubomibuhle.org.za/
ANOVA – APCE programme (not research but focussed on direct service delivery and technical assistance towards creating a centre of excellence in HIV care

Publications
  1. Abrams EJ, Woldesenbet S, Soares Silva J, Coovadia A, Black V, Technau KG, et al. Despite Access to Antiretrovirals for Prevention and Treatment, High Rates of Mortality Persist Among HIV-infected Infants and Young Children. The Pediatric infectious disease journal. 2017;36(6):595-601.
  2. Brown SA, Abbas S, Davies MA, Bunupuradah T, Sohn AH, Technau KG, et al. Brief Report: Pediatric Cancer Burden and Treatment Resources Within the Pediatric IeDEA Consortium. J Acquir Immune Defic Syndr. 2017;76(1):60-4.
  3. Fortuin-de Smidt M, de Waal R, Cohen K, Technau KG, Stinson K, Maartens G, et al. First-line antiretroviral drug discontinuations in children. PLoS One. 2017;12(2):e0169762.
  4. Penazzato M, Lule F, Essajee S. Paediatric HIV: the unfinished business. The Lancet HIV. 2017;4(10):e425-e7.
  5. Schomaker M, Leroy V, Wolfs T, Technau KG, Renner L, Judd A, et al. Optimal timing of antiretroviral treatment initiation in HIV-positive children and adolescents: a multiregional analysis from Southern Africa, West Africa and Europe. International journal of epidemiology. 2017;46(2):453-65.
  6. Shiau S, Strehlau R, Technau KG, Patel F, Arpadi SM, Coovadia A, et al. Early age at start of antiretroviral therapy associated with better virologic control after initial suppression in HIV-infected infants. AIDS. 2017;31(3):355-64.
  7. Technau KG, Kuhn L, Coovadia A, Carmona S, Sherman G. Improving early identification of HIV-infected neonates with birth PCR testing in a large urban hospital in Johannesburg, South Africa: successes and challenges. J Int AIDS Soc. 2017;20(1):21436.
  8. Technau KG, Kuhn L, Coovadia A, Murnane PM, Sherman G. Xpert HIV-1 point-of-care test for neonatal diagnosis of HIV in the birth testing programme of a maternity hospital: a field evaluation study. The lancet HIV. 2017;4(10):e442-e8.
  9. Technau KG, Mazanderani AH, Kuhn L, Hans L, Strehlau R, Abrams EJ, et al. Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort. J Int AIDS Soc. 2017;20(Suppl 6):21761.
  10. Inequality in outcomes for adolescents living with perinatally acquired HIV in sub-Saharan Africa: a Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Cohort Collaboration analysis. J Int AIDS Soc. 2018;21 Suppl 1.
  11. Goga A. Birth HIV testing and paediatric treatment programmes. The Lancet HIV. 2018.
  12. Luchters S, Technau K, Mohamed Y, Chersich MF, Agius PA, Pham MD, et al. The field performance and diagnostic accuracy of a low-cost instrument-free point-of-care CD4 test (VISITECT(R) CD4) performed by different health worker cadres among pregnant women. Journal of clinical microbiology. 2018.
  13. Patten G, Bernheimer J, Fairlie L, Rabie H, Sawry S, Technau K, et al. Lamivudine monotherapy as a holding regimen for HIV-positive children. PLoS One. 2018;13(10):e0205455.
  14. Patten G, Schomaker M, Davies MA, Rabie H, van Zyl G, Technau K, et al. What Should we do When HIV-Positive Children Fail First-Line Combination Antiretroviral Therapy? A Comparison of 4 ART Management Strategies. The Pediatric infectious disease journal. 2018.
  15. Technau KG, Strehlau R, Patel F, Shiau S, Burke M, Conradie M, et al. 12-month outcomes of HIV-infected infants identified at birth at one maternity site in Johannesburg, South Africa: an observational cohort study. The lancet HIV. 2018.
  16. Haeri Mazanderani A, Kufa T, Technau KG, Strehlau R, Patel F, Shiau S, et al. Early infant diagnosis HIV-1 PCR cycle-threshold predicts infant viral load at birth. J Clin Virol. 2019;114:21-5.
  17. Luchters S, Technau K, Mohamed Y, Chersich MF, Agius PA, Pham MD, et al. Field Performance and Diagnostic Accuracy of a Low-Cost Instrument-Free Point-of-Care CD4 Test (Visitect CD4) Performed by Different Health Worker Cadres among Pregnant Women. Journal of clinical microbiology. 2019;57(2).
  18. Patten G, Schomaker M, Davies MA, Rabie H, van Zyl G, Technau K, et al. What Should We Do When HIV-positive Children Fail First-line Combination Antiretroviral Therapy? A Comparison of 4 ART Management Strategies. The Pediatric infectious disease journal. 2019;38(4):400-5.
  19. Scorgie F, Mohamed Y, Anderson D, Crowe SM, Luchters S, Chersich MF. Qualitative assessment of South African healthcare worker perspectives on an instrument-free rapid CD4 test. BMC Health Serv Res. 2019;19(1):123.
  20. Strehlau R, Paximadis M, Patel F, Burke M, Technau KG, Shiau S, et al. HIV diagnostic challenges in breast-fed infants of mothers on antiretroviral therapy. AIDS. 2019;33(11):1751-6.
  21. Vreeman RC, Scanlon ML, Tu W, Slaven JE, McAteer CI, Kerr SJ, et al. Validation of a self-report adherence measurement tool among a multinational cohort of children living with HIV in Kenya, South Africa and Thailand. J Int AIDS Soc. 2019;22(5):e25304.
  22. Fairlie L, Sawry S, Patel F, Balkus JE, Kalk E, Mutevedzi P, et al. COVID-19 in pregnancy in South Africa: Tracking the epidemic and defining the natural history. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 2020;110(8):729-31.
  23. Haas AD, Technau KG, Pahad S, Braithwaite K, Madzivhandila M, Sorour G, et al. Mental health, substance use and viral suppression in adolescents receiving ART at a paediatric HIV clinic in South Africa. J Int AIDS Soc. 2020;23(12):e25644.
  24. Iyun V, Technau KG, Eley B, Rabie H, Boulle A, Fatti G, et al. Earlier Antiretroviral Therapy Initiation and Decreasing Mortality Among HIV-infected Infants Initiating Antiretroviral Therapy Within 3 Months of Age in South Africa, 2006-2017. The Pediatric infectious disease journal. 2020;39(2):127-33.
  25. Kufa T, Mazanderani AH, Sherman GG, Mukendi A, Murray T, Moyo F, et al. Point-of-care HIV maternal viral load and early infant diagnosis testing around time of delivery at tertiary obstetric units in South Africa: a prospective study of coverage, results return and turn-around times. J Int AIDS Soc. 2020;23(4):e25487.
  26. Kuhn L, Strehlau R, Shiau S, Patel F, Shen Y, Technau KG, et al. Early antiretroviral treatment of infants to attain HIV remission. EClinicalMedicine. 2020;18:100241.
  27. Mouton JP, Fortuin-de Smidt MC, Jobanputra N, Mehta U, Stewart A, de Waal R, et al. Serious adverse drug reactions at two children's hospitals in South Africa. BMC Pediatr. 2020;20(1):3.
  28. Moyo F, Haeri Mazanderani A, Murray T, Technau KG, Carmona S, Kufa T, et al. Characterizing Viral Load Burden Among HIV-Infected Women Around the Time of Delivery: Findings From Four Tertiary Obstetric Units in Gauteng, South Africa. J Acquir Immune Defic Syndr. 2020;83(4):390-6.
  29. Nyakato P, Davies MA, Technau KG, Fatti G, Rabie H, Tanser F, et al. Virologic response to efavirenz-based first-line antiretroviral therapy in children with previous exposure to antiretrovirals to prevent mother-to-child transmission. PLoS One. 2020;15(5):e0233693.
  30. Pham MD, Wise A, Garcia ML, Van H, Zheng S, Mohamed Y, et al. Improving the coverage and accuracy of syphilis testing: The development of a novel rapid, point-of-care test for confirmatory testing of active syphilis infection and its early evaluation in China and South Africa. EClinicalMedicine. 2020;24:100440.
  31. Pillay T, Cornell M, Fox MP, Euvrard J, Fatti G, Technau KG, et al. Recording of HIV viral loads and viral suppression in South African patients receiving antiretroviral treatment: a multicentre cohort study. Antivir Ther. 2020;25(5):257-66.
  32. Tsondai PR, Sohn AH, Phiri S, Sikombe K, Sawry S, Chimbetete C, et al. Characterizing the double-sided cascade of care for adolescents living with HIV transitioning to adulthood across Southern Africa. J Int AIDS Soc. 2020;23(1):e25447.
  33. Anderson K, Mutemaringa T, Technau KG, Johnson LF, Braithwaite K, Mokotoane E, et al. The next generation: Pregnancy in adolescents and women living with perinatally acquired HIV in South Africa. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 2021;111(3):260-4.
  34. Iyun V, Technau K-G, Vinikoor M, Yotebieng M, Vreeman R, Abuogi L, et al. Variations in the characteristics and outcomes of children living with HIV following universal ART in sub-Saharan Africa (2006–17): a retrospective cohort study. The Lancet HIV. 2021.
  35. Iyun V, Technau KG, Vinikoor M, Yotebieng M, Vreeman R, Abuogi L, et al. Variations in the characteristics and outcomes of children living with HIV following universal ART in sub-Saharan Africa (2006-17): a retrospective cohort study. The lancet HIV. 2021;8(6):e353-e62.
  36. Keal J, Mazanderani AH, van Dongen N, Sorour G, Technau KG. False-positive rapid diagnostic tests in paediatric and obstetric patients in South Africa. Southern African journal of HIV medicine. 2021;22(1):1186.
  37. Kuhn L, Paximadis M, Da Costa Dias B, Shen Y, Mncube S, Strehlau R, et al. Predictors of cell-associated HIV-1 DNA over one year in very early treated infants. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2021.
  38. Mukendi A, Kufa T, Sherman GG, Technau KG, Tiemessen CT, Mazanderani AH. Evaluation of the Aptima HIV-1 Quant Dx assay for HIV diagnosis at birth in South Africa. Diagnostic microbiology and infectious disease. 2021;101(3):115467.
  39. Nyakato P, Schomaker M, Sipambo N, Technau KG, Fatti G, Rabie H, et al. Virologic response of adolescents living with perinatally acquired HIV receiving antiretroviral therapy in the period of early adolescence (10-14 years) in South Africa. AIDS. 2021;35(6):971-8.
  40. Patel F, Shiau S, Strehlau R, Shen Y, Burke M, Paximadis M, et al. Low Pretreatment Viral Loads in Infants With HIV in an Era of High-maternal Antiretroviral Therapy Coverage. The Pediatric infectious disease journal. 2021;40(1):55-9.
  41. Tsondai PR, Davies MA, Singtoroj T, Maxwell N, McGowan CC, Songtaweesin WN, et al. Improving Methods to Classify Perinatal versus Nonperinatal HIV Acquisition in Young Adolescents 10-14 Years of Age. The Pediatric infectious disease journal. 2021;40(5):453-6.
  42. Zaniewski E, Brazier E, Ostinelli CHD, Wood R, Osler M, Technau KG, et al. Regression discontinuity analysis demonstrated varied effect of Treat-All on CD4 testing among Southern African countries. J Clin Epidemiol. 2021.

Awards/
Associations/
Community activities

Recognition for work in HIV at RMMCH - Ms Susan Jordaan (CEO) Gala event December 2009

Church Alive – Community Appreciation Certificate 2013

Best consultant/researcher category presentation/abstract at the Paediatric Research Day 26th October 2018
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